Preheat oven to 350°F. Spray an 8 1/2 x 4 1/2-inch loaf pan with nonstick cooking spray with flour. Set aside.
Stir together the pumpkin puree, 1/4 cup granulated sugar, vanilla bean paste, pumpkin pie spice, and egg. Set aside.
Stir together remaining 1/4 cup granulated sugar and 1 teaspoon cinnamon in a small bowl.
Open the can of biscuits and slice each in half horizontally, reshaping them into ovals or circles of about the same size. Coat each slice of biscuit dough with the cinnamon sugar mixture.
Lay one slice of dough flat on a cutting board. Spread some pumpkin mixture on top, then place another biscuit piece on top. Add more pumpkin mixture and continue stacking, spreading, and layering until you’re out of biscuits. You may have a bit of pumpkin mixture leftover.
Carefully place into the pan. It could be messy.
Bake for about 32 - 40 minutes, or until the top is golden and the center is cooked through.
Cool slightly before before removing from pan and glazing.
To make the glaze: Whisk the powdered sugar, cinnamon, heavy whipping cream and vanilla bean paste until smooth. Drizzle over loaf.
To serve: Using your fingers or a fork, pull apart.